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Total synthesis of tetronolide, the aglycon of tetrocarcins

โœ Scribed by Kei Takeda; Eiji Kawanishi; Hitoshi Nakamura; Eiichi Yoshii

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
230 KB
Volume
32
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The first total synthesis of tetronolide (1) has been achieved via coupling of spirotetronate 3 with octahydronaphthalene aldehyde I7 and subsequent macrocyclization of wsulfone-a-nldehydeone-a-aldehyde 2, leading to confirmation of the absolute configuration of 1.

Tetronolide (1) is the aglycon of antitumor antibiotics tetrocarcinsl which have been isolated from Micromonospora chalcea, and its stereostructure except absolute configuration was determined by X-ray

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