Enantioselective Total Synthesis of the
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S Chandrasekhar; M Venkat Reddy
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Article
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2000
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Elsevier Science
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French
β 136 KB
AbstractΓThe total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.