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Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series

✍ Scribed by Nolan R. Mente; Andrew J. Wiemer; Jeffrey D. Neighbors; John A. Beutler; Raymond J. Hohl; David F. Wiemer


Book ID
108074235
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
188 KB
Volume
17
Category
Article
ISSN
0960-894X

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Enantioselective Total Synthesis of the
✍ S Chandrasekhar; M Venkat Reddy πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 136 KB

AbstractÐThe total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.