𝔖 Bobbio Scriptorium
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Total synthesis of rifamycins. 2. Total synthesis of racemic rifamycin S

✍ Scribed by Iio, H.; Nagaoka, H.; Kishi, Y.


Book ID
121290266
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
445 KB
Volume
102
Category
Article
ISSN
0002-7863

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A regiospecific, Diels-Alder based synthesis of the naphthofuranone chromophore (1) of the rifamycins is described. The family of macrolides known as the rifamycins (e.g. L),l has attracted considerable synthetic interest recently. Most effort has focused on addressing the stereochemical problems em