Total synthesis of rifamycin W
β Scribed by Masaya Nakata; Nobutake Akiyama; Kyoko Kojima; Hirokazu Masuda; Mitsuhiro Kinoshita; Kuniaki Tatsuta
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 282 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A regiospecific, Diels-Alder based synthesis of the naphthofuranone chromophore (1) of the rifamycins is described. The family of macrolides known as the rifamycins (e.g. L),l has attracted considerable synthetic interest recently. Most effort has focused on addressing the stereochemical problems em
The formation of the macro ring of rifamycin S (4) has been accomplished by generating the lactam linkage through cyclization of a suitably protected and activated amino acid (4). 1 Previous papers from these laboratories on the synthesis of rifamycin S (1) have dealt with 2 in 80% yield occurs unde