A synthesis of the aromatic segment of rifamycin s
β Scribed by Hiroto Nagaoka; Gerard Schmid; Hideo Iio; Yoshito Kishi
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 223 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
We thank PD Dr. M. Zehnder and Dr. D. Bur. lnstitut fur Anorganische Chemie der Universitiit Basel, for this measurement.
A convenient method has been described
A regiospecific, Diels-Alder based synthesis of the naphthofuranone chromophore (1) of the rifamycins is described. The family of macrolides known as the rifamycins (e.g. L),l has attracted considerable synthetic interest recently. Most effort has focused on addressing the stereochemical problems em
Acid treatment of the hydroperoxide 5 yielded the enol ether 9. Hydrogenation of 9 gave the dihydro derivative, the structure of which was established by comparisonwith the substance synthesized by a different route. White, Martinelli, and Lancini have succeeded in the isolation of rifamycin W (l\_)