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Total Synthesis of (−)-Platensimycin, a Novel Antibacterial Agent

✍ Scribed by Ghosh, Arun K.; Xi, Kai


Book ID
121420828
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
257 KB
Volume
74
Category
Article
ISSN
0022-3263

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## Abstract **Epimerization and stapling in one pot**: A facile synthesis of an oxazinidinyl analogue of the antibiotic platensimycin is presented. Key steps of this work are a novel dynamic ring‐closing metathesis (RCM) that involves a base‐catalyzed epimerization followed by a tandem Ru‐catalyzed