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Total Synthesis of Platensimycin

โœ Scribed by K. C. Nicolaou; Ang Li; David J. Edmonds


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
130 KB
Volume
45
Category
Article
ISSN
0044-8249

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Total Synthesis of Platensimycin
โœ K. C. Nicolaou; Ang Li; David J. Edmonds ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 129 KB
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## Abstract **Epimerization and stapling in one pot**: A facile synthesis of an oxazinidinyl analogue of the antibiotic platensimycin is presented. Key steps of this work are a novel dynamic ringโ€closing metathesis (RCM) that involves a baseโ€catalyzed epimerization followed by a tandem Ruโ€catalyzed