Anatoxin-a has been synthesized in 8 steps, starting from succinimide, 4-bromo-l--butene and dimethyl (2-oxopropyl)phosphonate, by employing as the key step an intramolecular reaction of an N-acyliminium precursor with an cu,&unsaturated ketone moiety, induced by saturated HCl in MeOH at -5OOC. Ana
✦ LIBER ✦
Total Synthesis of Pinnamine and Anatoxin-a via a Common Intermediate. A Caveat on the Anatoxin-a Endgame
✍ Scribed by Hjelmgaard, Thomas; Søtofte, Inger; Tanner, David
- Book ID
- 115528868
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 228 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3263
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