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Total Synthesis of (+)-Nafuredin-γ Using a Highly Stereoselective Ti-Mediated Aldol Reaction

✍ Scribed by Onodera, Yuta; Suzuki, Takahiro; Kobayashi, Susumu


Book ID
118034599
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
366 KB
Volume
13
Category
Article
ISSN
1523-7060

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📜 SIMILAR VOLUMES


Stereoselective reactions: XIII. Total s
✍ Kiyoshi Tomioka; Kenji Koga 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 352 KB

carried out by treating 5 with 1.4-dibromobutane in dimethylformamide (DHF) in the presence of potassium tert-butoxide to afford 6 in 39% yield. Then focus was turned to the synthesis of deoxysesbanine (12). On the contrary to the easy alkoxycarbonylation of 4, treatment of 7 under the same reaction