## An efficient synthesis of the colchicine degradation product N-acetylcolchinol 1 is described featuring a thallium(lIl)-mediated intramolecular non-phenolic biaryl oxidative coupling reaction of intermediate U as the key step. Both the synthetic sample and that obtained from the degradation of co
โฆ LIBER โฆ
Total synthesis of N-nornitidine
โ Scribed by James H. Rigby; Daniel D. Holsworth
- Book ID
- 104225901
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 235 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
The benzo[c]phenanthridine alkaloid, N-nomitidine has been synthesized employing a benzpe-VinYl isocyanate cycloaddition as the key transfomration. The tetracyclic benzo[c]phenanthridines constitute an important sub-class of the isoquinoline alkaloid family' and a number of these species have elicited considerable synthetic1c,2 interest due to demonstrated anticancer activity.3*4 Although several representatives of this group of alkaloids display significant biological
๐ SIMILAR VOLUMES
Total Synthesis of (ยฑ)-N-Acetylcolchinol
โ
J.Scott Sawyer; Timothy L. Macdonald
๐
Article
๐
1988
๐
Elsevier Science
๐
French
โ 258 KB
Total Synthesis of (โ)-Calyciphylline N
โ
Shvartsbart, Artem; Smith, Amos B.
๐
Article
๐
2013
๐
American Chemical Society
๐
English
โ 709 KB
Total synthesis of (.+-.)-N-methylmaysen
โ
Corey, E. J.; Weigel, Leland O.; Floyd, David; Bock, Mark G.
๐
Article
๐
1978
๐
American Chemical Society
๐
English
โ 390 KB
Bioinspired Total Synthesis of Gymnothel
โ
Li, Huilin; Zhang, Yuanyuan; Xie, Xingang; Ma, Haichen; Zhao, Changgui; Zhao, Ga
๐
Article
๐
2014
๐
American Chemical Society
๐
English
โ 691 KB
Formal Total Synthesis of N -Methylmayse
โ
Wang, Lin; Gong, Jianxian; Deng, Lujiang; Xiang, Zheng; Chen, Zhixing; Wang, Yue
๐
Article
๐
2009
๐
American Chemical Society
๐
English
โ 558 KB
A total synthesis of N-acetylactinobolam
โ
Askin, David; Angst, Christof; Danishefsky, Samuel
๐
Article
๐
1985
๐
American Chemical Society
๐
English
โ 354 KB