๐”– Bobbio Scriptorium
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Total synthesis of N-nornitidine

โœ Scribed by James H. Rigby; Daniel D. Holsworth


Book ID
104225901
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
235 KB
Volume
32
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


The benzo[c]phenanthridine alkaloid, N-nomitidine has been synthesized employing a benzpe-VinYl isocyanate cycloaddition as the key transfomration. The tetracyclic benzo[c]phenanthridines constitute an important sub-class of the isoquinoline alkaloid family' and a number of these species have elicited considerable synthetic1c,2 interest due to demonstrated anticancer activity.3*4 Although several representatives of this group of alkaloids display significant biological


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