The benzo[c]phenanthridine alkaloid, N-nomitidine has been synthesized employing a benzpe-VinYl isocyanate cycloaddition as the key transfomration. The tetracyclic benzo[c]phenanthridines constitute an important sub-class of the isoquinoline alkaloid family' and a number of these species have elicit
โฆ LIBER โฆ
A total synthesis of N-acetylactinobolamine
โ Scribed by Askin, David; Angst, Christof; Danishefsky, Samuel
- Book ID
- 127285578
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 354 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-3263
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## An efficient synthesis of the colchicine degradation product N-acetylcolchinol 1 is described featuring a thallium(lIl)-mediated intramolecular non-phenolic biaryl oxidative coupling reaction of intermediate U as the key step. Both the synthetic sample and that obtained from the degradation of co
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