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Total Synthesis of (.+-.)-Mycothiazole and Formal Enantioselective Approach.

โœ Scribed by Alexandre Le Flohic; Christopher Meyer; Janine Cossy


Publisher
John Wiley and Sons
Year
2005
Weight
10 KB
Volume
36
Category
Article
ISSN
0931-7597

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Enantioselective formal total synthesis
โœ Frederick Calo; Jeffery Richardson; Andrew J.P. White; Anthony G.M. Barrett ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 428 KB

An enantioselective formal total synthesis of (ร€)-trachyspic acid was carried out using, as key steps, an asymmetric aldol reaction of a chiral oxazolidinone and a diastereoselective alkylation of a chiral 1,3dioxolan-2-one. The key lactone 3 was synthesized in five steps starting from dioxolanone 9