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Total Synthesis of (+)-Muconin

โœ Scribed by Yoshimitsu, Takehiko; Makino, Toshiyuki; Nagaoka, Hiroto


Book ID
125492780
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
118 KB
Volume
69
Category
Article
ISSN
0022-3263

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A convergent total synthesis of the tetrahydropyran-bearing acetogenin (ฯฉ)-muconin 1 is described. All five chiral building blocks 7, 9, 17, 21, and 29 were prepared from d-glutamic acid, respectively. Four out of them were used to furnish the alkyne 16 and the iodoalkyne 33, respectively, and palla