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Total Synthesis of Microsclerodermin E.

โœ Scribed by Jidong Zhu; Dawei Ma

Publisher
John Wiley and Sons
Year
2004
Weight
64 KB
Volume
35
Category
Article
ISSN
0931-7597

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Amphidinolide E (1) is a unique 18-membered macrolide isolated from the Y-5' strain of the dinoflagellate Amphidinium sp. [1] It exhibits cytotoxic activity against L1210 (IC 50 = 2.0 mg mL ร€1 ) and L5178Y (IC 50 = 4.8 mg mL ร€1 ) murine leukemia cells in vitro. Owing to its unique structural feature