✦ LIBER ✦

Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki–Hiyama–Kishi reaction

✍ Scribed by Christopher A. LeClair; Matthew B. Boxer; Craig J. Thomas; David J. Maloney

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 434 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.10.092

No coin nor oath required. For personal study only.

✦ Synopsis

A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6 0 -C7 0 bond.

📜 SIMILAR VOLUMES

ChemInform Abstract: Total Synthesis of

ChemInform Abstract: Total Synthesis of (-)-Decarestrictine D Through a Stereoselective Intramolecular Nozaki—Hiyama—Kishi Reaction.

✍ R. A. PILLI; M. M. VICTOR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Protecting-Group Directed Stereoselectiv

Protecting-Group Directed Stereoselective Intramolecular Nozaki–Hiyama–Kishi Reaction: A Concise and Efficient Total Synthesis of Amphidinolactone A

✍ Debendra K. Mohapatra; Pragna P. Das; Manas R. Pattanayak; Gaddamanugu Gayatri; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 459 KB 👁 1 views

Protecting-Group Directed Stereoselectiv

Protecting-Group Directed Stereoselective Intramolecular Nozaki–Hiyama–Kishi Reaction: A Concise and Efficient Total Synthesis of Amphidinolactone A (Eur. J. Org. Chem. 25/2010)

✍ Debendra K. Mohapatra; Pragna P. Das; Manas R. Pattanayak; Gaddamanugu Gayatri; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 884 KB

## Abstract **The cover picture shows** shows how a bulky protecting group directs the intramolecular Nozaki–Hiyama–Kishi reaction to afford exclusively one stereoisomer, whereas a small protecting group directs the reaction to afford both __anti__ and __syn__ isomers in a 2:1 ratio. Details are di