Protecting-Group Directed Stereoselective Intramolecular Nozaki–Hiyama–Kishi Reaction: A Concise and Efficient Total Synthesis of Amphidinolactone A (Eur. J. Org. Chem. 25/2010)

✍ Scribed by Debendra K. Mohapatra; Pragna P. Das; Manas R. Pattanayak; Gaddamanugu Gayatri; G. Narahari Sastry; J. S. Yadav

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 884 KB
• Volume: 2010
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201090067

✦ Synopsis

Abstract

The cover picture shows shows how a bulky protecting group directs the intramolecular Nozaki–Hiyama–Kishi reaction to afford exclusively one stereoisomer, whereas a small protecting group directs the reaction to afford both anti and syn isomers in a 2:1 ratio. Details are discussed in the article by D. K. Mohapatra, J. S. Yadav et al. on p. 4775 ff.