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Total synthesis of LeA-LacNAc pentasaccharide as a ligand for Clostridium difficiletoxin A

✍ Scribed by Zhang, Ping ;Ng, Kenneth ;Ling, Chang-Chun


Book ID
118222639
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
456 KB
Volume
8
Category
Article
ISSN
1477-0520

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Heparin is a sulfated glucosaminoglycan with a well-known anticoagulant activity' , and the active molecules have a high affinity for antithrombin III (AT-III), thereby enhancing the effects of this inhibitor on procoagulant proteases. The structures of highaffinity oligosaccharides, prepared from h