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Total Synthesis of (−)-Laulimalide

✍ Scribed by Ghosh, Arun K.; Wang, Yong

Book ID
127156446
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
41 KB
Volume
122
Category
Article
ISSN
0002-7863

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A stereocontrolled synthesis of the title compound is described. Key steps are an allylsilane addition to a chiral acetal as the major coupling step and a Yamaguchi macrolactonization for ring closure.