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Total synthesis of kanamycin-A

✍ Scribed by Minoru Nakajima; Akira Hasegawa; Norio Kurihara; Hisao Shibata; Tamio Ueno; Daikichi Nishimura

Publisher
Elsevier Science
Year
1968
Tongue
French
Weight
220 KB
Volume
9
Category
Article
ISSN
0040-4039

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✦ Synopsis

Kanamycin-A, discovered by Dmezawa and his coworkers (I) in 1957, is an antibiotic active against a variety of the Gram positive and Gram negative bacteria, especially against the mycobacteria, and now widely used as an antituberculous agent. The structure was demonstrated independently by Japanese and American-Canadian groups (Z-5) and the absolute configuration was established by Rinehart, Tatsuoka and their associates (6).

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Chemical modifications of kanamycin A Sy
Chemical modifications of kanamycin A Synthesis of 4β€³-deoxy and 4β€³-epi-halogenodeoxy kanamycin A
✍ R Albert; K Dax; A.E StΓΌtz; H Weidmann πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 137 KB

Stereospecific direct replacemant with inversion of configuration of 4"-OH by halogen in kanamycin A. Hydrogenolysis. Chemical modifications 1. in kanamycin A (I) have hitherto primarily focussed on the 6-aminodeoxy-D-glucose (X') part, found to be the predominant site of enzymatic deactivation. Exc