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Chemical modifications of kanamycin A Synthesis of 4″-deoxy and 4″-epi-halogenodeoxy kanamycin A

✍ Scribed by R Albert; K Dax; A.E Stütz; H Weidmann

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
137 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis

Stereospecific direct replacemant with inversion of configuration of 4"-OH by halogen in kanamycin A. Hydrogenolysis. Chemical modifications 1. in kanamycin A (I) have hitherto primarily focussed on the 6-aminodeoxy-D-glucose (X') part, found to be the predominant site of enzymatic deactivation. Except for the transformations at 6", alterations in the kanosamine (X") part are rather rare. 2,3

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