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The stereospecific synthesis of leukotriene A4 (LTA4), 5-epi-LTA4, 6-epi-LTA4 and 5-epi,6-epi-LTA4

โœ Scribed by Joshua Rokach; Robert Zamboni; Cheuk-Kun Lau; Yvan Guindon


Publisher
Elsevier Science
Year
1981
Tongue
French
Weight
257 KB
Volume
22
Category
Article
ISSN
0040-4039

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A novel stereospecific synthesis of (ยฑ)-
โœ Judith C. Buck; Frank Ellis; Peter C. North ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 142 KB

The reaction of the phosphonate 1 with the epoxyaldehyde 1 1s reported as the key step In a novel stereospeclfic synthesis of (+)-LTA4, methyl ester 1 The possible implication of the leukotrienes LTC4, D4 and E4 In Immediate hypersensitivity reactlons such as allergic asthma, has prompted much inte