Total Synthesis of Herbimycin A.
β Scribed by Sophie Canova; Veronique Bellosta; Antony Bigot; Patrick Mailliet; Serge Mignani; Janine Cossy
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 15 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Herbimycin A, an ansamycin antibiotic, is known to reverse the transformed phenotype of cells transfected with tyrosine kinase expressing oncogenes. The synthesis of [19β^3^H] herbimycin A (1c), a potential tool for unraveling the mechanism of this reversal, is described. Reduction of 1
Herbimycin is a new potent herbicidal antibiotic isolated from the cultured filtr te of wtr?i'r anwosynthetic means usin:)&-labeled precursors. re to ces (Sm.) h rosco icus AM-3672 We assign st cture 1 to herblmycin based on ' H-and The molecular formula, C30H42N209 for herbimycin (1) was establishe