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Synthesis of [19-3H] herbimycin A

✍ Scribed by Robert L. Dow; Bruce M. Bechle; Phillip M. Chalabi; James H. Windels; Robert W. Roth

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 234 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310409

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✦ Synopsis

Abstract

Herbimycin A, an ansamycin antibiotic, is known to reverse the transformed phenotype of cells transfected with tyrosine kinase expressing oncogenes. The synthesis of [19‐^3^H] herbimycin A (1c), a potential tool for unraveling the mechanism of this reversal, is described. Reduction of 19‐bromoherbimycin A (4) employing zinc‐copper couple/tritiated water affords hydroquinone (5c) which, when treated with manganese dioxide, affords 1c.

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