Total Synthesis of Griseolic Acid
β Scribed by Tulshian, Deen B.; Czarniecki, Michael
- Book ID
- 127321555
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 181 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0002-7863
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## Abstract Starting from [^14^C] ethyl orthoformate and amidine derivative 3 derived from griseolic acid in 6 steps, the synthesis of [2β^14^C] griseolic acid 9β²β(4βacetoxyβ3βgethoxybenzyl)ester [14C]β2, a promising antiglaucoma agent with its regioisomer [2β^14^C] griseolic acid 8β²β(4βacetoxyβ3βg
Total synthesis of (\*t\_)-gibberellic acid was accomplished via highly stereocontrolled route. A number of synthetic efforts for Cl9 -gibberellin phytohormones have been made in recent years. ' The total synthesis of gibberellic acid (gibberellin A3, GA3), a representative gibberellin, was complete