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Synthesis of [2-14C] griseolic acid 9′-(4-acetoxy-3-methoxybenzyl)ester, a antiglaucoma agent

✍ Scribed by Susumu Sato; Isamu Mikoshiba; Kenji Kawai; Koichi Hirai

Book ID
102368605
Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
389 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Starting from [^14^C] ethyl orthoformate and amidine derivative 3 derived from griseolic acid in 6 steps, the synthesis of [2‐^14^C] griseolic acid 9′‐(4‐acetoxy‐3‐gethoxybenzyl)ester [14C]‐2, a promising antiglaucoma agent with its regioisomer [2‐^14^C] griseolic acid 8′‐(4‐acetoxy‐3‐gethoxybenzyl)ester 9 and [2‐^14^C] griseolic acid [14C]‐1 has been achieved.

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