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Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation

✍ Scribed by Peixoto, Philippe A.; Richard, Jean-Alexandre; Severin, Rene; Chen, David Y.-K.


Book ID
118004313
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
38 KB
Volume
14
Category
Article
ISSN
1523-7060

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Total Synthesis of Echinopines A and B
✍ Nicolaou, K. C.; Ding, Hanfeng; Richard, Jean-Alexandre; Chen, David Y.-K. πŸ“‚ Article πŸ“… 2010 πŸ› American Chemical Society 🌐 English βš– 386 KB
Total synthesis of LL-Z1640-2 utilizing
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A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6 0 -C7 0 bond.