Total Synthesis of e pi -7-Deoxypancratistatin via Aza-Payne Rearrangement and Intramolecular Cyclization
โ Scribed by Rinner, Uwe; Siengalewicz, Peter; Hudlicky, Tomas
- Book ID
- 126294548
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 52 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The First Total Synthesis of (-)-Benzomalvin A via Intramolecular Aza-Wittig Reactions. -A short and efficient synthesis of the title compound (VII) starting from protected L-phenylalanine (I) is presented. Both ring skeletons of (VII) are constructed by intramolecular aza-Wittig reactions as the k
Key steps in this approach to umaryllidaceae alkaloids containing oxidation at the R-position of the pyrroline ring are (a) copper(H)-promoted rearrangement of aminocyclopentanol 11 to afford the 3-silylhydroindole 12, and (b) oxidation of 12 by the general procedures of Kumada and Fleming to give t