ChemInform Abstract: The First Total Synthesis of (-)-Benzomalvin A via Intramolecular Aza-Wittig Reactions.

✍ Scribed by T. SUGIMORI; T. OKAWA; S. EGUCHI; E. YASHIMA; Y. OKAMOTO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199804228

✦ Synopsis

The First Total Synthesis of (-)-Benzomalvin A via Intramolecular Aza-Wittig Reactions.

-A short and efficient synthesis of the title compound (VII) starting from protected L-phenylalanine (I) is presented. Both ring skeletons of (VII) are constructed by intramolecular aza-Wittig reactions as the key step. (VII) is an active neurokinin receptor antagonist. -