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Total synthesis of cularine alkaloids via dibenzoxepines as key intermediates

✍ Scribed by Alberto Garcia; Luis Castedo; Domingo Domínguez


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
960 KB
Volume
51
Category
Article
ISSN
0040-4020

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Total synthesis of haliclamine A, a macr
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The first total synthesis of haliclamine A (1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter-and intramolecular N-alkylations of 3-alkylpyridine derivatives 2