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Total Synthesis of (−)-Cleistenolide

✍ Scribed by Dokuburra Chanti Babu; Kankati Ashalatha; Chitturi Bhujanga Rao; Jon Paul Selvam Jondoss; Yenamandra Venkateswarlu

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
153 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

An efficient and short total synthesis of (−)‐cleistenolide (1) from D‐mannitol with an overall yield of 23.6% is described. The chiron approach for the synthesis of (−)‐cleistenolide involves a one‐C‐atom Wittig olefination, a selective allylic triethylsilyl protection, and a Grubbs‐catalyzed ring‐closure‐metathesis (RCM) reaction as the key steps.

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