Total Synthesis of Bryostatin 3
β Scribed by Ken Ohmori; Yasuyuki Ogawa; Tetsuo Obitsu; Yuichi Ishikawa; Shigeru Nishiyama; Shosuke Yamamura
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 128 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Asymmetric Synthesis of Bryostatin 2. -The title compound (Ia), which can be converted in 3 steps into the biologically active marine macrolide bryostatin 1 (Ib), is totally synthesized by coupling of 3 acyclic fragments.
The bryostatins are a unique family of cancer chemotherapeutic candidates isolated from marine bryozoa. While their molecular mode of action is not known, these macrolactones exhibit high affinities for protein kinase C (PKC) isozymes, compete for the phorbol ester binding site on PKC, and stimulate