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Total Synthesis of (−)-Bitungolide F

✍ Scribed by Su, Yingpeng; Xu, Yanfen; Han, Junjie; Zheng, Jiyue; Qi, Jing; Jiang, Tuo; Pan, Xinfu; She, Xuegong


Book ID
125528058
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
288 KB
Volume
74
Category
Article
ISSN
0022-3263

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The first total synthesis of (À)-bitungolide E is described. The key steps include a Myers' alkylation, modified Evans' syn aldol-reaction, using Crimmins protocol, Sharpless asymmetric epoxidation and ringclosing metathesis reaction.