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Total Synthesis of (+)-Azaspiracid-1. Part 2. Synthesis of the EFGHI Sulfone and Completion of the Synthesis.

✍ Scribed by David A. Evans; Travis B. Dunn; Lisbet Kvaernoe; Andre Beauchemin; Brian Raymer; Edward J. Olhava; Jason A. Mulder; Martin Juhl; Katsuji Kagechika; David A. Favor


Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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Total Synthesis of (+)-Azaspiracid-1. Pa
✍ Davidβ€…A. Evans; Travisβ€…B. Dunn; Lisbet KvΓ¦rnΓΈ; AndrΓ© Beauchemin; Brian Raymer; E πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 341 KB πŸ‘ 2 views

## Dedicated to Professor Dieter Seebach on the occasion of his 70th birthday With a practical synthesis of the ABCD aldehyde in hand (2, Scheme 1), [1] herein we describe our progress that culminated in the synthesis of (+)-azaspiracid-1 (1) in 26 linear steps and 2.7 % overall yield. As outline