Total synthesis of antitumor agents, (+)-goniopypyrone and (+)-7-epi-goniofufurone
✍ Scribed by Jean-Philippe Surivet; Jean-Michel Vatèle
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 126 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Synthesis of enantiopure (+)-7-epi-goniofufurone 1 and (+)-goniopypyrone 2 has been achieved from C-4 carbon chain chiron 3, readily available from (R)-mandelic acid.
📜 SIMILAR VOLUMES
The syntheses of the styryl lactones (+)-goniofufurone ( ) and (+)-7-epi-goniofufurone (2) from Dglucose are presented. The key steps are the formation of the lactone moiety by reaction of the hemiace~ais 15 and 16 with meldrum's acid (3) and the addition of phenylmagnesium bromide to the aldehydes
Application of the Reaction of D-
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