Synthesis of enantiopure (+)-7-epi-goniofufurone 1 and (+)-goniopypyrone 2 has been achieved from C-4 carbon chain chiron 3, readily available from (R)-mandelic acid.
A new synthesis of cytotoxic (+)-7-epi-Goniofufurone
β Scribed by Yang Min; Li Hong-Ming; Zhao Gang; Yu Qing-Sen; Ding Yu
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 418 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0256-7660
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π SIMILAR VOLUMES
The syntheses of the styryl lactones (+)-goniofufurone ( ) and (+)-7-epi-goniofufurone (2) from Dglucose are presented. The key steps are the formation of the lactone moiety by reaction of the hemiace~ais 15 and 16 with meldrum's acid (3) and the addition of phenylmagnesium bromide to the aldehydes
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Application of the Reaction of D-