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Total Synthesis of Amphidinolide E

โœ Scribed by Va, Porino; Roush, William R.

Book ID
121227014
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
69 KB
Volume
128
Category
Article
ISSN
0002-7863

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Amphidinolide E (1) is a unique 18-membered macrolide isolated from the Y-5' strain of the dinoflagellate Amphidinium sp. [1] It exhibits cytotoxic activity against L1210 (IC 50 = 2.0 mg mL ร€1 ) and L5178Y (IC 50 = 4.8 mg mL ร€1 ) murine leukemia cells in vitro. Owing to its unique structural feature

Total Synthesis of Amphidinolide E (I).
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