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Total synthesis of 4(RS)-F4t-isoprostane methyl ester

✍ Scribed by Thierry Durand; Alexandre Guy; Jean-Pierre Vidal; Jacques Viala; Jean-Claude Rossi

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
118 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The first total synthesis of 4(RS)-F 4t -isoprostane methyl ester 1 is described using diacetone-D-glucose as starting material. This new isoprostane (neuroprostane) would be very useful in neurological studies as a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in the human brain.

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