Total Synthesis of (−)-21-Isopentenylpaxilline
✍ Scribed by Smith, Amos B.; Cui, Haifeng
- Book ID
- 117999969
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 114 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-7060
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## Abstract An efficient, stereocontrolled total synthesis of the complex indole‐diterpene alkaloid (−)‐21‐isopentenylpaxilline (**1**) has been achieved. Key elements of the synthesis include the stereocontrolled construction of the advanced eastern hemisphere (−)‐**68**, involving a highly effici
Bleomycin A2 has been synthesized for the first time. Bleomycin (BLM) is an antitumor antibiotic clinically used in the treatment of squamous cell carcinoma, malignant lymphoma and testis tumors. BLM A2 (Q2), the major component of natural BLMs, consists of a linear hexapeptide named deglyco-BLM A2