Total Synthesis of (-)-21-Isopentenylpaxilline.
✍ Scribed by Amos B. III Smith; Haifeng Cui
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 68 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract An efficient, stereocontrolled total synthesis of the complex indole‐diterpene alkaloid (−)‐21‐isopentenylpaxilline (**1**) has been achieved. Key elements of the synthesis include the stereocontrolled construction of the advanced eastern hemisphere (−)‐**68**, involving a highly effici
## Abstract Reaction of 2,2^1^‐anhydrouridine (**2**) with [^82^Br]‐ammonium bromide in the presence of one equivalent p‐toluenesulfonic acid afforded 2^1^‐[^82^Br]‐2^1^‐deoxyuridine (**3**) in 73.4% chemical yield with a specific activity of 0.58 mCi mM^−1^. Alternatively, direct activation of 2^1
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