The total syntheses of the herbertane sesquiterpenes (±)-herbertene (1), (±)-b-herbertenol ( 2) and (±)-herbertenediol (5) have been successfully accomplished involving copper-catalysed conjugate addition of Grignard reagents to unsaturated compounds and a,a-dimethylation of primary esters as key re
✦ LIBER ✦
Total synthesis of (±)-1,13-herbertenediol, (±)-α-herbertenol and (±)-β-herbertenol
✍ Scribed by A. Srikrishna; G. Satyanarayana
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 210 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Total synthesis of a-herbertenol, b-herbertenol and 1,13-herbertenediol, employing a Claisen rearrangement and ring-closing metathesis as key reactions for the generation of the cyclopentane containing vicinal quaternary carbons, has been described.
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