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New total synthesis of (±)-herbertene, (±)-β-herbertenol and (±)-herbertenediol

✍ Scribed by Pranab Dutta Gupta; Ashutosh Pal; Arnab Roy; Debabrata Mukherjee

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
138 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total syntheses of the herbertane sesquiterpenes (±)-herbertene (1), (±)-b-herbertenol ( 2) and (±)-herbertenediol (5) have been successfully accomplished involving copper-catalysed conjugate addition of Grignard reagents to unsaturated compounds and a,a-dimethylation of primary esters as key reactions.

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