Total Synthesis, NMR Solution Structure, and Binding Model of the Potent Histone Deacetylase Inhibitor FR235222.
โ Scribed by Manuela Rodriguez; Stefania Terracciano; Elena Cini; Giulia Settembrini; Ines Bruno; Giuseppe Bifulco; Maurizio Taddei; Luigi Gomez-Paloma
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 17 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Various structurally modified analogues of FR235222 (**1**), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core i
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