Total Synthesis, NMR Solution Structure, and Binding Model of the Potent Histone Deacetylase Inhibitor FR235222
โ Scribed by Manuela Rodriquez; Stefania Terracciano; Elena Cini; Giulia Settembrini; Ines Bruno; Giuseppe Bifulco; Maurizio Taddei; Luigi Gomez-Paloma
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 281 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0044-8249
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๐ SIMILAR VOLUMES
## Abstract Various structurally modified analogues of FR235222 (**1**), a natural tetrapeptide inhibitor of mammalian histone deacetylases, were prepared in a convergent approach. The design of the compounds was aimed to investigate the effect of structural modifications of the tetrapeptide core i
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