✦ LIBER ✦

Total synthesis and stereochemical reassignment of tasiamide

✍ Scribed by Zhen-Hua Ma; Ni Song; Chun-Xia Li; Wei Zhang; Peng Wang; Ying-Xia Li

Book ID: 105359687
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 180 KB
Volume: 14
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.1051

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✦ Synopsis

Abstract

The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the N^α^‐Me‐L‐Gln of tasiamide to be N^α^‐Me‐D‐Gln, which was supported by ^1^H NMR, ^13^C NMR, COSY, HMQC, HMBC, and optical rotation. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.

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Total synthesis and stereochemical reassignment of tasiamide B

✍ Tiantian Sun; Wei Zhang; Chengli Zong; Peng Wang; Yingxia Li 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB

## Abstract The first total synthesis of tasiamide B, an octapeptide bearing 4‐amino‐3‐hydroxy‐5‐phenylpentanoic acid unit isolated from the marine cyanobacteria __Symploca__ sp. is described. A simple and efficient way was found to avoid the pyroglutamylation of __N__^α^‐Me‐Gln and led to a reassi