Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19 †
✍ Scribed by Paterson, Ian; Findlay, Alison D.; Florence, Gordon J.
- Book ID
- 120640359
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 112 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-7060
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## Abstract The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the __N__^α^‐Me‐L‐Gln of tasiamide to be __N__^α^‐Me‐D‐Gln, which was supported by ^1^H NMR, ^13^C NMR, COSY, HMQC, HMBC, and opt
## Abstract The first total synthesis of tasiamide B, an octapeptide bearing 4‐amino‐3‐hydroxy‐5‐phenylpentanoic acid unit isolated from the marine cyanobacteria __Symploca__ sp. is described. A simple and efficient way was found to avoid the pyroglutamylation of __N__^α^‐Me‐Gln and led to a reassi