Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives
✍ Scribed by Taejung Kim; Woojung Lee; Kyu Hyuk Jeong; Jung Ho Song; Soon-Hye Park; Pilju Choi; Su-Nam Kim; Seokjoon Lee; Jungyeob Ham
- Book ID
- 113496884
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 605 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-894X
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## Abstract The synthesis of the potent dual‐acting PPARα and PPARγ agonist NNC 61‐4655 labelled with tritium and carbon‐14 is reported. Tritium labelled NNC 61‐4655 was obtained in three steps with introduction of tritium through catalytic tritium‐halogen exchange of an aryl bromide precursor. Thi