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Total synthesis and cytotoxic activity of stellatin

✍ Scribed by Saeed, Aamer; Ashraf, Zaman; Rafique, Hummera


Book ID
115504965
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
128 KB
Volume
13
Category
Article
ISSN
1028-6020

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A simple and highly efficient stereoselective total synthesis of cytotoxic agent sporiolide A has been achieved starting from D-mannitol; the strategy of synthesis utilizes stereoselective zinc-mediated allylation, aldol coupling and ring-closing metathesis as key steps.