Total Syntheses of Zaragozic Acid
β Scribed by Dr. Ulrich Koert
- Book ID
- 102726876
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 567 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0044-8249
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π SIMILAR VOLUMES
## Abstract A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor **8** was synthesized starting from diβ__tert__βbutyl Dβtartrate (**47**) via an elevenβstep sequence involving the regioselective reduction of
A total synthesis of (+)-zaragozic acid C is described. Key steps are an acid-mediated acetonide deprotection-dithiane removal-ketalisation procedure, providing selectively the 2,8dioxabicyclo[3.2.1]octane core of the natural product, and the simultaneous introduction of the C3, C4 and C5 carboxylic
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