𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Total Syntheses of Variolin B and Deoxyvariolin B 1

✍ Scribed by Ahaidar, Abderaouf; Fernández, David; Danelón, Gerardo; Cuevas, Carmen; Manzanares, Ignacio; Albericio, Fernando; Joule, John A.; Álvarez, Mercedes


Book ID
118030844
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
181 KB
Volume
68
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Total synthesis of variolin B
✍ Regan J Anderson; Jonathan C Morris 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 110 KB

The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroace