✦ LIBER ✦

Total synthesis of variolin B

✍ Scribed by Regan J Anderson; Jonathan C Morris

Book ID: 104231926
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 110 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01881-0

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✦ Synopsis

The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid.

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